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GRB2 promotes brain metastasis in HER2-positive breast cancer by regulating the Ras/MAPK pathway

Abstract Brain metastasis is emerging as the most serious concern for breast cancer patients. HER2-positive breast cancer is more prone to undergo brain metastasis than other subtypes; notably, there has been little improvement in the treatment of brain metastasis .Our study confirmed the relevance...

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Autors principals: Hongyu Li, Yalin Zhang, Xiao Han, Bingyu Li, Dan Liu, Gang Sun
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2025-04-01
Col·lecció:Scientific Reports
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Accés en línia:https://doi.org/10.1038/s41598-025-99685-3
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