Neutrophil membrane-coated circular RNA nanoparticles for targeted immunotherapy in HER2-positive breast cancer brain metastasis

Abstract Breast cancer is the most prevalent malignancy worldwide, with approximately 50% of HER2-positive advanced breast cancer patients eventually developing brain metastases, significantly reducing survival. Current HER2-targeted therapies, such as trastuzumab, exhibit limited efficacy in patien...

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Autori principali:	Yunpeng Liu, Wei He, Xiaoju Li, Xiyan Lu, Chihua Wu, Yuan Gao, Dong Fan, Chao Dong, Huadong Zhao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-07-01
Serie:	Cell Communication and Signaling
Soggetti:	HER2-positive breast cancer Brain metastases Circular RNA Immunotherapy Blood-brain barrier Tumor microenvironment
Accesso online:	https://doi.org/10.1186/s12964-025-02321-w
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