Effects of Inosine-5′-monophosphate Dehydrogenase (IMPDH/GuaB) Inhibitors on <i>Borrelia burgdorferi</i> Growth in Standard and Modified Culture Conditions

<i>Borrelia burgdorferi</i>’s inosine-5′-monophosphate dehydrogenase (IMPDH, GuaB encoded by the <i>guaB</i> gene) is a potential therapeutic target. GuaB is necessary for <i>B. burgdorferi</i> replication in mammalian hosts but not in standard laboratory culture conditions. Therefore, we cannot tes...

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Үндсэн зохиолчид:	Eric L. Siegel, Connor Rich, Sanchana Saravanan, Patrick Pearson, Guang Xu, Stephen M. Rich
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2024-10-01
Цуврал:	Microorganisms
Нөхцлүүд:	<i>Borrelia burgdorferi</i> inosine-5′-monophosphate dehydrogenase GuaB Lyme disease
Онлайн хандалт:	https://www.mdpi.com/2076-2607/12/10/2064
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!