Effects of Inosine-5′-monophosphate Dehydrogenase (IMPDH/GuaB) Inhibitors on <i>Borrelia burgdorferi</i> Growth in Standard and Modified Culture Conditions

<i>Borrelia burgdorferi</i>’s inosine-5′-monophosphate dehydrogenase (IMPDH, GuaB encoded by the <i>guaB</i> gene) is a potential therapeutic target. GuaB is necessary for <i>B. burgdorferi</i> replication in mammalian hosts but not in standard laboratory culture conditions. Therefore, we cannot tes...

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Egile Nagusiak:	Eric L. Siegel, Connor Rich, Sanchana Saravanan, Patrick Pearson, Guang Xu, Stephen M. Rich
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2024-10-01
Saila:	Microorganisms
Gaiak:	<i>Borrelia burgdorferi</i> inosine-5′-monophosphate dehydrogenase GuaB Lyme disease
Sarrera elektronikoa:	https://www.mdpi.com/2076-2607/12/10/2064
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