Targeted Epstein–Barr virus capture sequencing identifies BBLF4-L322M as an independent prognostic variant in nasopharyngeal carcinoma

ABSTRACT Epstein–Barr virus (EBV) is etiologically linked to nasopharyngeal carcinoma (NPC) and shows geographic heterogeneity. To determine whether viral genotype affects prognosis, we performed capture-based whole-genome sequencing of EBV from 114 Guangxi NPC biopsies (mean breadth ~93%, depth ~97...

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Hlavní autoři:	Shi Luo, Zongjian Huang, Nan Shi, Fangfang Chen, Weiren Xiang, Yu Ren, Wei Xia, Anzhou Tang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2026-06-01
Edice:	Microbiology Spectrum
Témata:	Epstein–Barr virus (EBV) nasopharyngeal carcinoma (NPC) viral prognostic biomarkers capture-based whole-genome sequencing BBLF4-L322M
On-line přístup:	https://journals.asm.org/doi/10.1128/spectrum.02927-25
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