Targeted Epstein–Barr virus capture sequencing identifies BBLF4-L322M as an independent prognostic variant in nasopharyngeal carcinoma

ABSTRACT Epstein–Barr virus (EBV) is etiologically linked to nasopharyngeal carcinoma (NPC) and shows geographic heterogeneity. To determine whether viral genotype affects prognosis, we performed capture-based whole-genome sequencing of EBV from 114 Guangxi NPC biopsies (mean breadth ~93%, depth ~97...

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Hauptverfasser:	Shi Luo, Zongjian Huang, Nan Shi, Fangfang Chen, Weiren Xiang, Yu Ren, Wei Xia, Anzhou Tang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2026-06-01
Schriftenreihe:	Microbiology Spectrum
Schlagworte:	Epstein–Barr virus (EBV) nasopharyngeal carcinoma (NPC) viral prognostic biomarkers capture-based whole-genome sequencing BBLF4-L322M
Online-Zugang:	https://journals.asm.org/doi/10.1128/spectrum.02927-25
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