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Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

Ivermectin is a gold standard anthelmintic drug that works by potently depressing neuronal activity and muscular contractility in arthropods and nematodes. At the molecular level, ivermectin activates inhibitory glutamate-gated chloride channels (GluClRs), which are found exclusively in invertebrate...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Timothy eLynagh, Joe eLynch
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2012-05-01
Schriftenreihe:Frontiers in Molecular Neuroscience
Schlagworte:
Online-Zugang:http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00060/full
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