Process to Remove the Size Variants Contained in the Antibody–Chelator Complex PCTA-NCAB001 for Radiolabeling with Copper-64

Understanding the physicochemical properties of antibody–drug conjugates is critical to assess their quality at manufacturing and monitor them during subsequent storage. For radiometal–antibody complexes, it is important to control the properties of the antibody–chelator conjugate to maintain the qu...

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主要な著者:	Yukie Yoshii, Hiroki Matsumoto, Chika Igarashi, Tomoko Tachibana, Fukiko Hihara, Mitsuhiro Shinada, Atsuo Waki, Sei Yoshida, Kenichiro Naito, Kimiteru Ito, Tatsuya Higashi, Hiroaki Kurihara, Makoto Ueno
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2023-09-01
シリーズ:	Pharmaceuticals
主題:	antibody–drug conjugates antibody–chelator conjugates chromatography size exclusion multi-angle light scattering hydrophobic interaction chromatography
オンライン･アクセス:	https://www.mdpi.com/1424-8247/16/10/1341
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