Process to Remove the Size Variants Contained in the Antibody–Chelator Complex PCTA-NCAB001 for Radiolabeling with Copper-64

Understanding the physicochemical properties of antibody–drug conjugates is critical to assess their quality at manufacturing and monitor them during subsequent storage. For radiometal–antibody complexes, it is important to control the properties of the antibody–chelator conjugate to maintain the qu...

Szczegółowa specyfikacja

Opis bibliograficzny

Główni autorzy:	Yukie Yoshii, Hiroki Matsumoto, Chika Igarashi, Tomoko Tachibana, Fukiko Hihara, Mitsuhiro Shinada, Atsuo Waki, Sei Yoshida, Kenichiro Naito, Kimiteru Ito, Tatsuya Higashi, Hiroaki Kurihara, Makoto Ueno
Format:	Artigo
Język:	Inglês
Wydane:	MDPI AG 2023-09-01
Seria:	Pharmaceuticals
Hasła przedmiotowe:	antibody–drug conjugates antibody–chelator conjugates chromatography size exclusion multi-angle light scattering hydrophobic interaction chromatography
Dostęp online:	https://www.mdpi.com/1424-8247/16/10/1341
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