One pot synthesis of pyrazolo-piperazine-quinazoline hybrids: evaluation of anticancer activity, molecular docking and ADMET studies

The synthesis of pyrazolo-piperazine-quinazoline hybrids (7a-n) was described, and their anticancer activity was assessed towards two cancer cell lines, such as HepG2 (hepatocellular carcinoma) and MCF-7 (breast cancer). The results show that three hybrids, 7e, 7f, and 7g, displayed good activity co...

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Detalhes bibliográficos

Principais autores:	Pandaga Saidulu, Saikrishna Balabadra, Srinivas Bandari, KrishnareddyValluru, Ravinder Manchal
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-06-01
Colecção:	Results in Chemistry
Assuntos:	Pyrazolo-piperazine-quinazoline hybrids In vitro anti-cancer activity Anti-VEGFR-2 activity Molecular docking ADMET studies
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211715626002122
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