Near-infrared duocarmycin photorelease from a Treg-targeted antibody-drug conjugate improves efficacy of PD-1 blockade in syngeneic murine tumor models

Regulatory T cells (Tregs) play a crucial role in mediating immunosuppression in the tumor microenvironment. Furthermore, Tregs contribute to the lack of efficacy and hyperprogressive disease upon Programmed cell death protein 1 (PD-1) blockade immunotherapy. Thus, Tregs are considered a promising t...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Hiroshi Fukushima, Aki Furusawa, Seiichiro Takao, Ebaston Thankarajan, Michael P Luciano, Syed Muhammad Usama, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Motofumi Suzuki, Miyu Kano, Peter L Choyke, Martin J Schnermann, Hisataka Kobayashi
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Taylor & Francis Group 2024-12-01
سلاسل:	OncoImmunology
الموضوعات:	Antibody-drug conjugate near-infrared light PD-1 blockade photouncaging regulatory T cell
الوصول للمادة أونلاين:	https://www.tandfonline.com/doi/10.1080/2162402X.2024.2370544
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!