Combined CD25-targeted near infrared photoimmunotherapy (NIR-PIT) and intratumor IL-15 enhance the effectiveness of anti-PD-1 immunotherapy

Abstract Immunotherapies aimed at enhancing anti-cancer immunity are now in wide clinical use. For instance, anti-programmed cell death protein 1 (PD-1) monoclonal antibody (mAb) therapy has demonstrated clinical efficacy in many tumor types, but overall, only a minority of patients respond. Near-in...

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Principais autores:	Makoto Kano, Aki Furusawa, Hiroshi Fukushima, Seiichiro Takao, Shuhei Okuyama, Hiroshi Yamamoto, Motofumi Suzuki, Miyu Kano, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2025-12-01
coleção:	Cancer Immunology, Immunotherapy
Assuntos:	Anti-PD-1 monoclonal antibody CD8/regulatory T cell ratio Hyperprogression Interleukin-15 Near-infrared photoimmunotherapy
Acesso em linha:	https://doi.org/10.1007/s00262-025-04186-x
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