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Targeting IL-6 by engineered Lactococcus lactis via surface-displayed affibody

Abstract Background Dysregulated production of interleukin (IL)-6 is implicated in the pathology of inflammatory bowel disease (IBD). Neutralization of IL-6 in the gut by safe probiotic bacteria may help alleviate intestinal inflammation. Here, we developed Lactococcus lactis with potent and selecti...

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Principais autores: Abida Zahirović, Aleš Berlec
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2022-07-01
סדרה:Microbial Cell Factories
נושאים:
Inflammatory bowel disease
IL-6
Microbiota
Lactococcus lactis
Delivery system
גישה מקוונת:https://doi.org/10.1186/s12934-022-01873-7
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