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Transcriptional modulation induced by ionizing radiation: p53 remains a central player

Abstract The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The DNA damage response (DDR), most robustly mobilized by double‐strand breaks (DSBs), rapidly activates an extensive signaling network that affects numerous c...

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Principais autores: Sharon Rashi‐Elkeles, Ran Elkon, Seagull Shavit, Yaniv Lerenthal, Chaim Linhart, Ana Kupershtein, Ninette Amariglio, Gideon Rechavi, Ron Shamir, Yosef Shiloh
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2011-08-01
Series:Molecular Oncology
Assuntos:
DNA damage response
Ionizing radiation
Gene expression
Meta-analysis
Transcriptional regulation
p53
Acceso en liña:https://doi.org/10.1016/j.molonc.2011.06.004
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