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Cannabidiol’s cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a median 5 year-survival rate of 12%. Cannabidiol (CBD) has been found to exhibit antineoplastic potential and may potentiate the anticancer effects of cytotoxic’s such as gemcitabine. CBD therapy h...

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Principais autores: Nagina Mangal, Vikash Reebye, Nagy Habib, Mikael H. Sodergren
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-05-01
Serier:Journal of Cannabis Research
Fag:
CBD
Cannabidiol
Pancreatic cancer
PDAC
Ceramide
CerS1
Online adgang:https://doi.org/10.1186/s42238-024-00227-x
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