Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts

Extracellular matrix mineralization is critical for osteogenesis, and its dysregulation could result in osteoporosis and vascular calcification. IKK/NF-κB activation inhibits differentiation of osteoblasts, and reduces extracellular matrix mineralization, however the underlying mechanisms are poorly...

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Autori principali:	Qianyun Hao, Zhuangzhuang Liu, Liaoxun Lu, Lichen Zhang, Li Zuo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2020-02-01
Serie:	Frontiers in Endocrinology
Soggetti:	osteoblasts IKKβ NF-κB JNK1 JNK2 CRISPR/Cas9
Accesso online:	https://www.frontiersin.org/article/10.3389/fendo.2020.00013/full
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