Targeting caspase-8/c-FLIPL heterodimer in complex II promotes DL-mediated cell death

Death receptor (DR) networks are controlled by the assembly of the Death-Inducing Signaling Complex (DISC) and complex II. The family of small molecules FLIPins (FLIP interactors) were developed to target the caspase-8/c-FLIPL heterodimer. FLIPin compounds were shown to promote apoptosis and caspase...

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Autors principals:	Laura K. Hillert-Richter, Corinna König, Nikita V. Ivanisenko, Dirk Reinhold, Inna N. Lavrik
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2024-09-01
Col·lecció:	Frontiers in Cell and Developmental Biology
Matèries:	cell death complex II c-FLIP FLIPin caspase-8 SMAC mimetic
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1471216/full
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