6-methylflavone exerts selective antimycobacterial activity with membrane energetics disruption and demonstrates therapeutic potential against Mycobacterium abscessus infection

ABSTRACT Treatment of nontuberculous mycobacteria (NTM) diseases, especially Mycobacterium abscessus pulmonary disease, remains a major clinical challenge due to its broad antibiotic resistance and limited therapeutic options. To search for new candidates, we established a synthetic flavonoid librar...

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Váldodahkkit:	Jaehun Oh, Jeong-Won Shin, Hyejun Seo, Hyung-Jun Kim, Nam-Jung Kim, Bum-Joon Kim
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Microbiology 2026-06-01
Ráidu:	Microbiology Spectrum
Fáttát:	nontuberculous mycobacteria Mycobacterium abscessus 6-methylflavone flavonoids narrow-spectrum antibiotics membrane energetics disruptors
Liŋkkat:	https://journals.asm.org/doi/10.1128/spectrum.03588-25
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