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6-methylflavone exerts selective antimycobacterial activity with membrane energetics disruption and demonstrates therapeutic potential against Mycobacterium abscessus infection

ABSTRACT Treatment of nontuberculous mycobacteria (NTM) diseases, especially Mycobacterium abscessus pulmonary disease, remains a major clinical challenge due to its broad antibiotic resistance and limited therapeutic options. To search for new candidates, we established a synthetic flavonoid librar...

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Principais autores: Jaehun Oh, Jeong-Won Shin, Hyejun Seo, Hyung-Jun Kim, Nam-Jung Kim, Bum-Joon Kim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-06-01
Serier:Microbiology Spectrum
Fag:
nontuberculous mycobacteria
Mycobacterium abscessus
6-methylflavone
flavonoids
narrow-spectrum antibiotics
membrane energetics disruptors
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.03588-25
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