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Efficiency of ultrasound-guided placental gene therapy in a rabbit IUGR model and effects on offspring development

Placental insufficiency is a major cause of intrauterine growth restriction (IUGR), and no effective prenatal therapy is currently available. Previous studies have demonstrated that gene therapies based on overexpression of insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor...

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Principais autores: María Soledad Trigo, Antonio Gonzalez-Bulnes, Pilar García-Rebollar, Nora Formoso-Rafferty, Teresa Cejalvo, Javier García-Castro, Natalia Yeste-Vizcaíno, Alicia Barbero-Fernández
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-09-01
Serier:Frontiers in Veterinary Science
Fag:
adenoviral vectors
gene therapy
IGF-1
IUGR
rabbit
VEGF
Online adgang:https://www.frontiersin.org/articles/10.3389/fvets.2025.1633597/full
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