Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%. Dysregulation of fatty acid (FA) metabolism is associated with MM development and progression; however, the underlying mechanisms remain unclear. Herein, we explore the roles of long‐chain fatty acid coe...

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Detalhes bibliográficos

Principais autores:	Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-06-01
Colecção:	Molecular Oncology
Assuntos:	ACSL cell metabolism fatty acid hematological malignancies multiple myeloma Triacsin C
Acesso em linha:	https://doi.org/10.1002/1878-0261.13794
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