Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%. Dysregulation of fatty acid (FA) metabolism is associated with MM development and progression; however, the underlying mechanisms remain unclear. Herein, we explore the roles of long‐chain fatty acid coe...

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Autori principali:	Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-06-01
Serie:	Molecular Oncology
Soggetti:	ACSL cell metabolism fatty acid hematological malignancies multiple myeloma Triacsin C
Accesso online:	https://doi.org/10.1002/1878-0261.13794
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