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In Silico Evaluation of Some Computer-Designed Fluoroquinolone–Glutamic Acid Hybrids as Potential Topoisomerase II Inhibitors with Anti-Cancer Effect

<b>Background/Objectives:</b> Fluoroquinolones (FQs) are topoisomerase II inhibitors with antibacterial activity, repositioned recently as anti-cancer agents. Glutamic acid (GLA) is an amino acid that affects human metabolism. Since an anti-cancer mechanism of FQs is human topoisomerase II inhibitio...

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Principais autores: Octavia-Laura Oancea, Șerban Andrei Gâz, Gabriel Marc, Ioana-Andreea Lungu, Aura Rusu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-11-01
coleção:Pharmaceuticals
Assuntos:
fluoroquinolones
glutamic acid
hybrids
etoposide
anti-cancer potential
huma topoisomerase II beta-DNA complex
Acesso em linha:https://www.mdpi.com/1424-8247/17/12/1593
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