In Silico Evaluation of Some Computer-Designed Fluoroquinolone–Glutamic Acid Hybrids as Potential Topoisomerase II Inhibitors with Anti-Cancer Effect

<b>Background/Objectives:</b> Fluoroquinolones (FQs) are topoisomerase II inhibitors with antibacterial activity, repositioned recently as anti-cancer agents. Glutamic acid (GLA) is an amino acid that affects human metabolism. Since an anti-cancer mechanism of FQs is human topoisomerase II inhibitio...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	Octavia-Laura Oancea, Șerban Andrei Gâz, Gabriel Marc, Ioana-Andreea Lungu, Aura Rusu
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2024-11-01
Cyfres:	Pharmaceuticals
Pynciau:	fluoroquinolones glutamic acid hybrids etoposide anti-cancer potential huma topoisomerase II beta-DNA complex
Mynediad Ar-lein:	https://www.mdpi.com/1424-8247/17/12/1593
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!