The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas
Abstract A subset of gliomas has DNA repair defects that lead to hypermutated genomes. While such tumors are resistant to alkylating chemotherapies, they may also express more mutant neoantigens on their cell surfaces, and thus be more responsive to immunotherapies. A fast, inexpensive method of scr...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BMC
2020-02-01
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| Edice: | Acta Neuropathologica Communications |
| Témata: | |
| On-line přístup: | https://doi.org/10.1186/s40478-020-0892-2 |
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