Transcriptomic analysis identifies the neuropeptide cortistatin (CORT) as an inhibitor of temozolomide (TMZ) resistance by suppressing the NF-κB-MGMT signaling axis in human glioma

Glioma is a common tumor originating in the brain that has a high mortality rate. Temozolomide (TMZ) is the first-line treatment for high-grade gliomas. However, a large proportion of gliomas are resistant to TMZ, posing a great challenge to their treatment. In the study, the specific functions and...

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Главные авторы:	Zongze He, Bo Peng, Qi Wang, Jie Tian, Ping Liu, Jie Feng, Yiwei Liao, Longyi Chen, Ping Jia, Jian Tang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	KeAi Communications Co., Ltd. 2024-05-01
Серии:	Genes and Diseases
Предметы:	Cortistatin Glioma MGMT NF-κB pathway Temozolomide
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2352304223002222
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