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Empagliflozin rescues pro-arrhythmic and Ca2+ homeostatic effects of transverse aortic constriction in intact murine hearts

Abstract We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2–6 weeks) challenge resulted in reduced late Na+ currents, and increased...

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Kaydedildi:
Asıl Yazarlar: Qiang Wen, Rui Zhang, Kejun Ye, Jun Yang, Hangchuan Shi, Zhu Liu, Yangpeng Li, Ting Liu, Shiyu Zhang, Wanpei Chen, Jingjing Wu, Weichao Liu, Xiaoqiu Tan, Ming Lei, Christopher L.-H. Huang, Xianhong Ou
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2024-07-01
Seri Bilgileri:Scientific Reports
Konular:
Empagliflozin
Transverse aortic constriction (TAC)
Heart failure
Ca2+ homeostasis
Action potential duration
Ventricular arrhythmia
Online Erişim:https://doi.org/10.1038/s41598-024-66098-7
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