Empagliflozin rescues pro-arrhythmic and Ca2+ homeostatic effects of transverse aortic constriction in intact murine hearts

Abstract We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2–6 weeks) challenge resulted in reduced late Na+ currents, and increased...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Qiang Wen, Rui Zhang, Kejun Ye, Jun Yang, Hangchuan Shi, Zhu Liu, Yangpeng Li, Ting Liu, Shiyu Zhang, Wanpei Chen, Jingjing Wu, Weichao Liu, Xiaoqiu Tan, Ming Lei, Christopher L.-H. Huang, Xianhong Ou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-07-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Empagliflozin Transverse aortic constriction (TAC) Heart failure Ca2+ homeostasis Action potential duration Ventricular arrhythmia
Online-Zugang:	https://doi.org/10.1038/s41598-024-66098-7
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!