Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2
The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 (Nsp1-C-ter) from SARS-CoV-2 bind in the mRNA entry channel of the 40S ribosomal subunit and blocks mRNA entry, thereby shutting down...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications Ltd
2022-03-01
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| Serie: | eLife |
| Soggetti: | |
| Accesso online: | https://elifesciences.org/articles/74877 |
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