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The Gq signalling pathway inhibits brown and beige adipose tissue

Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes.

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Auteurs principaux: Katarina Klepac, Ana Kilić, Thorsten Gnad, Loren M. Brown, Beate Herrmann, Andrea Wilderman, Aileen Balkow, Anja Glöde, Katharina Simon, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Wess, Marc Freichel, Matthias Blüher, Gabi König, Evi Kostenis, Paul A. Insel, Alexander Pfeifer
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2016-03-01
Collection:Nature Communications
Accès en ligne:https://doi.org/10.1038/ncomms10895
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