Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

Abstract Adaptation to chronic hypoxia occurs through changes in protein expression, which are controlled by hypoxia-inducible factor 1α (HIF1α) and are necessary for cancer cell survival. However, the mechanisms that enable cancer cells to adapt in early hypoxia, before the HIF1α-mediated transcrip...

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Hlavní autoři:	Fiona Grimm, Agustín Asuaje, Aakriti Jain, Mariana Silva dos Santos, Jens Kleinjung, Patrícia M Nunes, Stefanie Gehrig, Louise Fets, Salihanur Darici, James I MacRae, Dimitrios Anastasiou
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2024-03-01
Edice:	The EMBO Journal
Témata:	Hypoxia Glycolysis HIF1α Metabolism α-Ketoglutarate
On-line přístup:	https://doi.org/10.1038/s44318-024-00065-w
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