Bulky pcDNA plasmid encoding Leishmania- and Sandfly-derived antigens resulted in transient Th1 response post Leishmania major infection in BALB/c mice

Abstract Leishmaniasis is a common parasitic infection in tropical regions worldwide, and yet there is no effective human vaccine available. The results of leishmanization in animal models have emphasized the role of antigen persistence after recovery from the disease. It is argued that alternative...

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Autors principals:	Negar Seyed, Hamzeh Sarvnaz, Sima Habibzadeh, Roya Yousefi, Zahra Eghbali, Elham Gholami, Tahereh Taheri, Sima Rafati
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-05-01
Col·lecció:	Scientific Reports
Matèries:	Leishmania major Multi-protein DNA vaccine Antibiotic-free plasmid Electroporation
Accés en línia:	https://doi.org/10.1038/s41598-026-52313-0
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