Bulky pcDNA plasmid encoding Leishmania- and Sandfly-derived antigens resulted in transient Th1 response post Leishmania major infection in BALB/c mice

Abstract Leishmaniasis is a common parasitic infection in tropical regions worldwide, and yet there is no effective human vaccine available. The results of leishmanization in animal models have emphasized the role of antigen persistence after recovery from the disease. It is argued that alternative...

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Principais autores:	Negar Seyed, Hamzeh Sarvnaz, Sima Habibzadeh, Roya Yousefi, Zahra Eghbali, Elham Gholami, Tahereh Taheri, Sima Rafati
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-05-01
coleção:	Scientific Reports
Assuntos:	Leishmania major Multi-protein DNA vaccine Antibiotic-free plasmid Electroporation
Acesso em linha:	https://doi.org/10.1038/s41598-026-52313-0
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