mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

<p>Abstract</p> <p>Group II metabotropic glutamate receptors (mGluRs) couple to the inhibitory G-protein Gi. The group II mGluRs include two subtypes, mGlu2 and mGlu3, and their pharmacological activation produces analgesic effects in inflammatory and neuropathic pain states. However, the specific c...

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Bibliografische Detailangaben

Hauptverfasser:	Copani Agata, Traficante Anna, Montana Michael C, Chiechio Santina, Zammataro Magda, Nicoletti Ferdinando, Gereau Robert W
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	SAGE Publishing 2011-01-01
Schriftenreihe:	Molecular Pain
Online-Zugang:	http://www.molecularpain.com/content/7/1/6
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