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In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator

mGlu5 receptor-mediated polyphosphoinositide (PI) hydrolysis is classically measured by determining the amount of radioactivity incorporated in inositolmonophosphate (InsP) after labeling of membrane phospholipids with radioactive inositol. Although this method is historically linked to the study of...

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Principais autores: Anna R. Zuena, Luisa Iacovelli, Rosamaria Orlando, Luisa Di Menna, Paola Casolini, Giovanni Sebastiano Alemà, Gabriele Di Cicco, Giuseppe Battaglia, Ferdinando Nicoletti
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-07-01
Serier:Frontiers in Pharmacology
Fag:
mGlu5 receptors
receptor signaling
polyphosphoinositide hydrolysis
InsP levels
VU0360172
MTEP
Online adgang:https://www.frontiersin.org/article/10.3389/fphar.2018.00804/full
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