Recombinant AAV genome size effect on viral vector production, purification, and thermostability

Adeno-associated virus (AAV) has shown great promise as a viral vector for gene therapy in clinical applications. The present work studied the effect of genome size on AAV production, purification, and thermostability by producing AAV2-GFP using suspension-adapted HEK293 cells via triple transfectio...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Nermin Ibreljic, Benjamin E. Draper, Carl W. Lawton
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2024-03-01
Цуврал:	Molecular Therapy: Methods & Clinical Development
Нөхцлүүд:	gene therapy adeno-associated virus viral genome titer capsid titer triple transfection anion exchange chromatography
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2329050124000044
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!