Recombinant AAV genome size effect on viral vector production, purification, and thermostability

Adeno-associated virus (AAV) has shown great promise as a viral vector for gene therapy in clinical applications. The present work studied the effect of genome size on AAV production, purification, and thermostability by producing AAV2-GFP using suspension-adapted HEK293 cells via triple transfectio...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Nermin Ibreljic, Benjamin E. Draper, Carl W. Lawton
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2024-03-01
Sarja:	Molecular Therapy: Methods & Clinical Development
Aiheet:	gene therapy adeno-associated virus viral genome titer capsid titer triple transfection anion exchange chromatography
Linkit:	http://www.sciencedirect.com/science/article/pii/S2329050124000044
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