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Phosphorylation Mimetic of Myosin Regulatory Light Chain Mitigates Cardiomyopathy-Induced Myofilament Impairment in Mouse Models of RCM and DCM

This study focuses on mimicking constitutive phosphorylation in the N-terminus of the myosin regulatory light chain (S15D-RLC) as a rescue strategy for mutation-induced cardiac dysfunction in transgenic (Tg) models of restrictive (RCM) and dilated (DCM) cardiomyopathy caused by mutations in essentia...

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Kaydedildi:
Asıl Yazarlar: Katarzyna Kazmierczak, Jingsheng Liang, Luis G. Maura, Natissa K. Scott, Danuta Szczesna-Cordary
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2023-06-01
Seri Bilgileri:Life
Konular:
cardiomyopathy
myosin RLC
myosin ELC
N-terminal protein modification
S15D-RLC phosphomimetic
super-relaxed state (SRX)
Online Erişim:https://www.mdpi.com/2075-1729/13/7/1463
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