Phosphorylation Mimetic of Myosin Regulatory Light Chain Mitigates Cardiomyopathy-Induced Myofilament Impairment in Mouse Models of RCM and DCM

This study focuses on mimicking constitutive phosphorylation in the N-terminus of the myosin regulatory light chain (S15D-RLC) as a rescue strategy for mutation-induced cardiac dysfunction in transgenic (Tg) models of restrictive (RCM) and dilated (DCM) cardiomyopathy caused by mutations in essentia...

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Hlavní autoři:	Katarzyna Kazmierczak, Jingsheng Liang, Luis G. Maura, Natissa K. Scott, Danuta Szczesna-Cordary
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-06-01
Edice:	Life
Témata:	cardiomyopathy myosin RLC myosin ELC N-terminal protein modification S15D-RLC phosphomimetic super-relaxed state (SRX)
On-line přístup:	https://www.mdpi.com/2075-1729/13/7/1463
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