Comparison of two doses of leucovorin in severe low-dose methotrexate toxicity – a randomized controlled trial

Abstract Background Leucovorin (folinic acid) is a commonly used antidote for severe toxicity with low-dose methotrexate, but its optimum dose is unclear, varying from 15 to 25 mg every 6-h. Methods Open-label RCT included patients with severe low-dose (≤ 50 mg/week) methotrexate toxicity defined as...

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Autors principals:	Mudit Bhargava, Chirag Rajkumar Kopp, Shankar Naidu, Deba Prasad Dhibar, Atul Saroch, Alka Khadwal, Tarun Narang, Siddharth Jain, Aastha Khullar, Bidya Leishangthem, Aman Sharma, Susheel Kumar, Shefali Sharma, Sanjay Jain, Varun Dhir
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2023-05-01
Col·lecció:	Arthritis Research & Therapy
Matèries:	Methotrexate Toxicity Folinic acid Leucovorin Overdose Poisoning
Accés en línia:	https://doi.org/10.1186/s13075-023-03054-2
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