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Comparison of two doses of leucovorin in severe low-dose methotrexate toxicity – a randomized controlled trial

Abstract Background Leucovorin (folinic acid) is a commonly used antidote for severe toxicity with low-dose methotrexate, but its optimum dose is unclear, varying from 15 to 25 mg every 6-h. Methods Open-label RCT included patients with severe low-dose (≤ 50 mg/week) methotrexate toxicity defined as...

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Principais autores: Mudit Bhargava, Chirag Rajkumar Kopp, Shankar Naidu, Deba Prasad Dhibar, Atul Saroch, Alka Khadwal, Tarun Narang, Siddharth Jain, Aastha Khullar, Bidya Leishangthem, Aman Sharma, Susheel Kumar, Shefali Sharma, Sanjay Jain, Varun Dhir
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2023-05-01
Colecção:Arthritis Research & Therapy
Assuntos:
Methotrexate
Toxicity
Folinic acid
Leucovorin
Overdose
Poisoning
Acesso em linha:https://doi.org/10.1186/s13075-023-03054-2
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