Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models

Previous studies have shown that local delivery of tumor antigen-specific CD8+ T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious. Peritoneal dissemination of cancer is a frequent and often fatal patient condition usually diagnosed when the tumor burden is...

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Principais autores:	Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Irene Olivera, Elizabeth Bolaños, José González-Gomariz, Maite Álvarez, Iñaki Etxeberria, Belen Palencia, Álvaro Teijeira, Ignacio Melero, Pedro Berraondo, Fernando Aranda
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Taylor & Francis Group 2023-12-01
סדרה:	OncoImmunology
נושאים:	Peritoneal carcinomatosis interleukin 12 adoptive cell transfer mRNA locoregional treatment
גישה מקוונת:	https://www.tandfonline.com/doi/10.1080/2162402X.2022.2147317
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