Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection

Dimethyl fumarate (DMF), an antioxidant/anti-inflammatory drug approved for the treatment of multiple sclerosis, induces antioxidant enzymes, in part through transcriptional upregulation. We hypothesized that DMF administration to simian immunodeficiency virus (SIV)-infected rhesus macaques would in...

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Autores principales:	Yoelvis Garcia-Mesa, He N. Xu, Patricia Vance, Analise L. Gruenewald, Rolando Garza, Cecily Midkiff, Xavier Alvarez-Hernandez, David J. Irwin, Alexander J. Gill, Dennis L. Kolson
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2021-03-01
Colección:	Antioxidants
Materias:	SIV HIV-associated neurocognitive disorders fumaric acid esters dimethyl fumarate DMF oxidative stress
Acceso en línea:	https://www.mdpi.com/2076-3921/10/3/416
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