Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1

Abstract Double-strand breaks (DSBs) due to genotoxic stress represent potential threats to genome stability. Dysfunctional telomeres are recognized as DSBs and are repaired by distinct DNA repair mechanisms. RAP1 and TRF2 are telomere binding proteins essential to protect telomeres from engaging in...

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Principais autores:	Rekha Rai, Kevin Biju, Wenqi Sun, Tori Sodeinde, Amer Al-Hiyasat, Jaida Morgan, Xianwen Ye, Xueqing Li, Yong Chen, Sandy Chang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-04-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-023-37761-w
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