atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure

We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current ge...

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Autores principales:	Laure Fournier Le Ray, Alexandra Aubry, Wladimir Sougakoff, Matthieu Revest, Jérôme Robert, Isabelle Bonnet, Nicolas Veziris, Florence Morel
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Centers for Disease Control and Prevention 2022-05-01
Colección:	Emerging Infectious Diseases
Materias:	tuberculosis atpE bedaquiline MDR TB XDR TB Rv0678
Acceso en línea:	https://wwwnc.cdc.gov/eid/article/28/5/21-2517_article
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