Targeting the ferritinophagy axis: multi-target regulation of TFRC/FTH1/NCOA4 by artesunate ameliorates salivary gland dysfunction in Sjögren’s Disease

Abstract Background Sjögren’s Disease (SJD) is an autoimmune disorder involving lymphocytic infiltration of exocrine glands, notably salivary and lacrimal glands, causing dysfunction. Ferroptosis, an iron-dependent cell death pathway, contributes to glandular injury. Ferritinophagy, regulated by the...

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Главные авторы:	Yong Luo, Liuting Zeng, Yaru Zheng, Xiaomin Li, Mingjuan Liu, Ningyu Guo, Genghong Yao, Lingyun Sun
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2026-03-01
Серии:	Chinese Medicine
Предметы:	Sjögren’s Disease Artesunate Ferritinophagy Ferroptosis TFRC/FTH1/NCOA4 axis Single-cell transcriptomics
Online-ссылка:	https://doi.org/10.1186/s13020-026-01354-8
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