Targeting the ferritinophagy axis: multi-target regulation of TFRC/FTH1/NCOA4 by artesunate ameliorates salivary gland dysfunction in Sjögren’s Disease

Abstract Background Sjögren’s Disease (SJD) is an autoimmune disorder involving lymphocytic infiltration of exocrine glands, notably salivary and lacrimal glands, causing dysfunction. Ferroptosis, an iron-dependent cell death pathway, contributes to glandular injury. Ferritinophagy, regulated by the...

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Príomhchruthaitheoirí:	Yong Luo, Liuting Zeng, Yaru Zheng, Xiaomin Li, Mingjuan Liu, Ningyu Guo, Genghong Yao, Lingyun Sun
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	BMC 2026-03-01
Sraith:	Chinese Medicine
Ábhair:	Sjögren’s Disease Artesunate Ferritinophagy Ferroptosis TFRC/FTH1/NCOA4 axis Single-cell transcriptomics
Rochtain ar líne:	https://doi.org/10.1186/s13020-026-01354-8
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