Ministring DNA (msDNA): a novel linear covalently-closed DNA with enhanced stability for gene and cell therapy applications

Abstract The quality and fidelity of DNA vectors used in genetic medicine and gene therapy either as starting material for manufacturing or as therapeutic ingredients play a critical role in determining ultimate clinical success. Ministring DNA (msDNA), is a novel minivector that is a linear covalen...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Wai Kuen Hung, Siddarth Chandrasekaran, Olga Zaslaver, Ming Zhu, Jamie Lam, Steven Hersch, Peyman Mokarami, Roderick A. Slavcev, Nafiseh Nafissi
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2025-05-01
Цуврал:	Scientific Reports
Нөхцлүүд:	Keywords Ministring DNA Linear covalently closed DNA Gene therapy Chemical and mechanical stability Lyophilization
Онлайн хандалт:	https://doi.org/10.1038/s41598-025-98730-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!