Ministring DNA (msDNA): a novel linear covalently-closed DNA with enhanced stability for gene and cell therapy applications

Abstract The quality and fidelity of DNA vectors used in genetic medicine and gene therapy either as starting material for manufacturing or as therapeutic ingredients play a critical role in determining ultimate clinical success. Ministring DNA (msDNA), is a novel minivector that is a linear covalen...

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Hlavní autoři:	Wai Kuen Hung, Siddarth Chandrasekaran, Olga Zaslaver, Ming Zhu, Jamie Lam, Steven Hersch, Peyman Mokarami, Roderick A. Slavcev, Nafiseh Nafissi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-05-01
Edice:	Scientific Reports
Témata:	Keywords Ministring DNA Linear covalently closed DNA Gene therapy Chemical and mechanical stability Lyophilization
On-line přístup:	https://doi.org/10.1038/s41598-025-98730-5
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