Dynamics of tertiary lymphoid structures and immune cross talk in early versus advanced colorectal cancer: potential implications for immunotherapy

Abstract Background Irrespective of microsatellite status, immune checkpoint inhibitor therapy shows superior efficacy in early-stage colorectal cancer (CRC) compared to advanced cases. The distinctions of the tumor microenvironment (TME) and tertiary lymphoid structure (TLS) between early- and adva...

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Autori principali:	Zixu Chen, Bang Hu, Keyu Cai, Han Gao, Zhenyu Xian, Shuang Zhang, Zhen Fang, Qian Zhou, Donglin Ren, Qi Zou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2025-04-01
Serie:	Cancer Immunology, Immunotherapy
Soggetti:	Tumor microenvironment Immunotherapy Tertiary lymphoid structure Colorectal cancer
Accesso online:	https://doi.org/10.1007/s00262-025-04027-x
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